Indocyanine Green azide, ICG azide

ICG azide

 210.00 1345.00

Labeling via azide/alkyne click-chemistry

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Introduction

The non-invasive near-infrared (NIR) fluorescence imaging dye Indocyanine green (ICG) is approved by the United States Food and Drug administration (FDA) for ophthalmologic angiography to determine cardiac output and liver blood flow and function. This dye is also used in cancer patients for the detection of solid tumors, localization of lymphnodes, and for angiography during reconstructive surgery, visualization of retinal and choroidal vasculature, and photodynamic therapy. In cancer diagnostics and therapeutics, ICG could be used as both an imaging dye and a hyperthermia agent.

ICG is a tricarbocyanine-type dye with NIR-absorbing properties (peak absorption around 800 nm) and emission maximum at 807 nm (10% v/vDMSO/PBS). Little absorption in the visible range accounts for the low autofluorescence, tissue absorbance, and scattering at NIR wavelengths (700-900 nm).

This azide can be used to label alkyne-tagged biomolecules (like proteins, lipids, nucleic acids, sugars) chemoselectively via click-chemistry.

Material Amount Storage Stability
ICG azide 0.5 mg
  • -20 °C
  • Dessicate
  • Protect from light
When stored as directed, reactive probes are stable for at least 3 months
1 mg
5 mg
Color

Dark green powder

Label

azide

Product Size

1 kit

Detection Method

Fluorescence, optoacoustic

Excitation Class

Near infrared, NIR

Excitation/Emission maximum (nm)

790/830

Solubility

DMSO, DMF, Acetonitrile, Methanol

Molecular Weight

931.21 g.mol-1

Formula

C53H66N6O7S

Shipping Condition

RT

Regulatory Statement

For Research Use Only. Not for use in diagnostic procedures.

Quantity

1 mg, 5 mg, 10 mg

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