art-hydrogen peroxitrace probe

PeroxiTrace

 210.00 1345.00

Hydrogen Peroxide Bioluminescent Probe

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Introduction

Hydrogen peroxide is a cytotoxic reactive oxygen species (ROS) produced in living organisms in a number of physiological reations1. High concentrations of hydrogen peroxide are produced in the development of a number of diseases such as diabetes, cardiovascular diseases and cancer2.

The PeroxiTrace bioluminescent probe from Intrace Medical is the second generation of the known hydrogen peroxide probe3 that has been optimized for applied research. The probe possesses increased water solubility which eliminates the need to use high concentrations of organic co-solvents.

PeroxiTrace probe allows to visualize hydrogen peroxide fluxes in vivo in small living animals expressing luciferase using the highly sensitive bioluminescent technique.

Material Amount Storage Stability

PeroxiTrace

(Hydrogen Peroxide Bioluminescent Probe)

1 mg
  • -20 °C
  • Dessicate
  • Protect from light
When stored as directed, reactive probes are stable for at least 6 months
5 mg
10 mg

Although PeroxiTrace probe is soluble in water if high concentration solutions have to be used some organic co-solvent (e.g. DMSO) might be required to aid solubility.

For examples of cell and animal experiments please refer to ref. 3.

  1. Long, L. H., et al. Hydrogen Peroxide. Ubiquitous in Cell Culture and In Vivo. UEBUM Life, 2000, 50, 251
  2. Tsien, R. Y., et al. In Vivo Targeting of Hydrogen Peroxide by Activatable Cell-Penetrating Peptides, J. Am. Chem. Soc. 2014, 136, 874
  3. Chang, C., at al. In Vivo Imaging of Hydrogen Peroxide Production in a Murine Tumor Model with a Chemoselective Bioluminescent Reporter, PNAS, 2010, 107, 21316
Color

White powder

Product Size

1 kit

Detection Method

Bioluminescence

Solubility

DMSO, DMF, Methanol, Water

Molecular Weight

452.34 g.mol-1

Shipping Condition

RT (store at -20°C after receiving)

Regulatory Statement

For Research Use Only. Not for use in diagnostic procedures.

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